The Journal of Health, Population and Nutrition
Vol. 38, No. 1, 2019, pp. 1-8
Bioline Code: hn19005
Full paper language: English
Document type: Research Article
Document available free of charge
The Journal of Health, Population and Nutrition, Vol. 38, No. 1, 2019, pp. 1-8
© Copyright 2019 - The Author(s)
Comparison of biochemical parameters among DPP4 inhibitor users and other oral hypoglycaemic drug users: a cross-sectional study from Anuradhapura, Sri Lanka|
Rathish, Devarajan; Jayasumana, Channa & Agampodi, Suneth
Background: Higher efficacy of incretin-based therapies for type 2 diabetes mellitus has been reported from Asia.
Pancreatitis and hepatitis have also been suspected to occur due to dipeptidyl peptidase-4 inhibitor (DPP4I) treatment.
The present study aims at comparing selected biochemical parameters among DPP4 inhibitor users and other oral
hypoglycaemic drug users.
Methods: Patients were recruited from the State Pharmaceutical Corporation, Anuradhapura, Sri Lanka, for a comparative
cross-sectional study. Two groups were involved: “DPP4I” user group (n = 63) and “other oral hypoglycaemic” user group
(n = 126). Mann-Whitney U test was performed to find a significant difference (p < 0.05) in the distributions of HbA1C,
pancreatic amylase, serum lipase, AST and ALT levels between the two groups.
Results: Contradicting to previous Asian studies, distribution of HbA1C (p = 0.569) between anti-diabetic regimes with and
without DPP4 inhibitors showed no significant difference. Also, amylase (p = 0.171), AST (p = 0.238) and ALT (p = 0.347)
failed to show significance. However, lipase was significantly (p = 0.012) high in the DPP4I group.
Conclusion: The study showed a significantly higher lipase level among the DPP4I users in comparison to other oral
hypoglycaemic drug users, and possible reasons were discussed.
Diabetes mellitus; HbA1C; Amylase; Lipase; AST; ALT; Pancreatitis; Hepatitis; Safety; Efficacy
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