Background: Fagara zanthoxyloides
is a well known medicinal plant in Uganda. It is used extensively in malaria and other infections. However nothing is known about its toxicity.
The objective of the study was to evaluate the acute toxicity of the methanolic extract of the root-bark of F. zanthoxyloides
, in mice.
Methanolic extract of the root-bark of the plant was administered orally to mice at various dose levels to determine the acute toxic effects and the median lethal dose (LD50
) in mice.
of the methanolic extract was found to be 5.0 g/Kg body weight within 95 % confidence limits. The mice showed signs of cerebral irritation before dying. Histopathological examinations of the viscera showed congestion and focal necrosis of the liver and renal tubules.
It was concluded that the extract of F. zanthoxyloides
is safe, however the cerebral mechanism that lead to the death of the mice need to be investigated further.