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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 8, No. 2, 2008, pp. 74-79
Bioline Code: hs08018
Full paper language: English
Document type: Research Article
Document available free of charge

African Health Sciences, Vol. 8, No. 2, 2008, pp. 74-79

 en Anti-Seizure Activity of the Aqueous Leaf Extract of Solanum Nigrum check for this species in other resources Linn (solanaceae) in Experimental Animals
Wannang, Noel N.; Anuka, Joseph A.; Kwanashie, Helen O.; Gyang, Steven S. & Auta, Asa


Background: Solanum nigrum check for this species in other resources is claimed in traditional medical practice, to be useful in the treatment of epilepsy in some parts of Nigeria.
Objectives: To study the anti-convulsant property of the aqueous extract of the leaves of S. nigrum in chicks, mice and rats.
Method: Aqueous extracts were administered intraperitoneally, at a pre-treatment time of 30 minutes, at graded doses and animals were challenged with different types of proconvulsants.
Results: The aqueous leaf extract produced a significantly (P <0.05) dose dependent protection against electrically-induced seizure in chicks and rats, pentylenetetrazole-induced seizure in mice and rats and picrotoxin-induced seizure in mice and rats. The anti-seizure property of the extract was potentiated by amphetamine.
Conclusion: The result obtained in this study suggests that the leaves of this plant may possess anti-convulsant property in chicks, mice and rats.

Solanum nigrum; anti-seizure activity; chicks; mice; rats

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