African Health Sciences
Makerere University Medical School
Vol. 9, No. 4, 2009, pp. 275-278
Bioline Code: hs09065
Full paper language: English
Document type: Research Article
Document available free of charge
African Health Sciences, Vol. 9, No. 4, 2009, pp. 275-278
© Copyright 2009 - Makerere Medical School, Uganda
Synthesis, characterization and biological activities of substituted cinnoline culphonamides|
Vikas, S & Darbhamulla, S
The Cinnoline moiety and Sulphonamide moiety both have good antimicrobial properties.
In the present study both the moieties were condensed to synthesize substituted cinnoline sulphonamide derivatives using intramolecular cyclization followed by diazotization in order to get synergistic activity.
These derivatives particularly halogen substituted cinnoline derivatives showed potent antimicrobial activity.
Further investigations are required to find out possible mechanism of action.
Cinnoline, Antibacterial, Antifungal