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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 10, No. 1, 2010, pp. 2-8
Bioline Code: hs10002
Full paper language: English
Document type: Research Article
Document available free of charge

African Health Sciences, Vol. 10, No. 1, 2010, pp. 2-8

 en Trace elements and Vitamin E status in Nigerian patients with prostate cancer
Adaramoye, O.A.; Akinloye, O. & Olatunji, I.K.


Background: Prostate cancer is the most common type of cancer among men.

Objectives: To investigate the trace elements (Se, Zn, Cu and Cd) and vitamin E status of some Nigerian prostate cancer (PCa) patients relative to their prostate-specific antigen (PSA) values.

Methods: Prostate cancer patients were assigned into groups 1, 2 and 3 with PSA of 5-10 ng/ml, 11-20 ng/ml and > 20 ng/ ml, respectively.

Results: The results showed that the levels of whole blood superoxide dismutase (SOD) and serum Se and Zn were significantly lower (p< 0.05) in the PCa patients. Specifically, levels of SOD, Se and Zn decreased by 67%, 30% and 35%; 70%, 52% and 41%; 81%, 58% and 47%, in subjects with PSA of 5-10 ng/ml, 11-20 ng/ml and > 20 ng/ml, respectively. There were no significant differences (p > 0.05) in levels of Cu and Cd. Serum Cu/ Zn ratio were significantly higher in PCa patients. The Cu/Zn ratios were 1: 1.2: 1.3 for subjects in groups 1, 2 and 3, respectively. Vitamin E levels in PCa patients were significantly lower and followed the order; normal > PSA (5-10) > PSA (11-20) > PSA (> 20).

Conclusions: Deficiency of vitamin E, Zn and Se may be risk factors for development of PCa.

Lipid peroxidation, Prostate cancer, PSA values, Trace elements, Vitamin E

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