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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 10, No. 1, 2010, pp. 93-98
Bioline Code: hs10017
Full paper language: English
Document type: Special Article
Document available free of charge

African Health Sciences, Vol. 10, No. 1, 2010, pp. 93-98

 en Hepatocellular carcinoma and the underlying mechanisms
Oyagbemi, A.A.; Azeez, O.I. & Saba, A.B.


The incidence of hepatocellular carcinoma is increasing worldwide as well as the associated risk factors, some of which include exposure to aflatoxin B1, Hepatitis B (HBV) virus and hepatitis C (HCV) virus. Mutation of tumour suppressor gene p53 at codon 249ser at exon 7 has been found to contribute significantly to replication of damaged DNA and subsequent tumour progression. The x gene of HBV (HBx) is the most common open reading frame integrated into the host genome in hepatocellular carcinoma and the integrated HBx is frequently mutated in hepatocellular carcinoma. Mutant HBx proteins still retain their ability to bind to p53 thereby attenuating DNA repair and p53-mediated apoptosis.

hepatocellular carcinoma, aflatoxin B1, HBV, HCV, p53

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