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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 10, No. 2, 2010, pp. 111-116
Bioline Code: hs10022
Full paper language: English
Document type: Research Article
Document available free of charge

African Health Sciences, Vol. 10, No. 2, 2010, pp. 111-116

 en In vitro susceptibility of Plasmodium falciparum check for this species in other resources to monodesethylamodiaquine, quinine, mefloquine and halofantrine in Abidjan (Côte d'Ivoire)
Yavo, W.; Bla, K.B.; Djaman, A.J.; Assi, S.B.; Basco, L.K.; Mazabraud, A. & Koné, M.


Background: Malaria is the primary cause of hospitalization in Cτte d′Ivoire. Early treatment is one of the strategies to control this illness. However, the spread of resistance of Plasmodium falciparum check for this species in other resources to antimalarial drugs can seriously compromise this strategy.
Objectives: The aim of this study was to assess the in vitro susceptibility of P. falciparum to monodesethylamodiaquine and aminoalcohols in Abidjan (Cτte d′Ivoire).
Methods: We assessed the in vitro susceptibility of isolates collected from patients with uncomplicated malaria by using the WHO optical microtest technique.
Results: The proportions of resistance to monodesethylamodiaquine, mιfloquine and halofantrine were 12.5%, 15.6% and 25.9%, respectively. For quinine, none of isolates showed evidence of in vitro resistance. However, two isolates (6.1%) had IC 50 values above 300 nM. The IC 50 of each drug was positively and significantly correlated to that of the other three drugs, and the correlation was higher between halofantrine and mefloquine.
Conclusions: Our results showed that the in vitro chloroquine resistance reported in previous studies has been extended to other antimalarial drugs investigated in this study except for quinine. Therefore, it is necessary to implement a long-term monitoring system of antimalarial drug resistance.

in vitro test, Plasmodium falciparum, monodesethylamodiaquine, quinine, mefloquine, halofantrine, Abidjan (Côte d′Ivoire).

© Copyright 2010 African Health Sciences.

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