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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 12, No. 1, 2012, pp. 41-47
Bioline Code: hs12007
Full paper language: English
Document type: Research Article
Document available free of charge

African Health Sciences, Vol. 12, No. 1, 2012, pp. 41-47

 en Changes in plasma IL4, TNF-α and CRP in response to regular passive smoking at home among healthy school children in Khartoum, Sudan
Merghani, TH; Saeed, A & Alawad, A


Background: Regular exposure to tobacco smoke at home causes airway inflammation and altered cytokine regulation; however, there is variation between individuals of different countries.
Objective: To determine effects of passive smoking on plasma IL4, TNF-α, and CRP in healthy male school-children in Khartoum.
Methods: A total of 135 male school-pupils (69 passive smokers and 66 non-smokers) were selected randomly from three primary schools for boys in Khartoum. Information about smoking history was collected from each pupil and his parents using a questionnaire. Plasma CRP, IL4 and TNFá were measured using commercially available ELISA kits.
Results: Plasma IL4 and TNF-α in the passive smokers (mean ± SEM) is at 2.92 ± 0.93 and 19.78 ± 4.67 pg/ml respectively; whereas in the non-smokers . It is at 0.45 ± 0.28 and 5.05 ± 1.54 pg/ml respectively. The difference between the two groups is statistically significant (p < 0.05). The mean plasma IL4 and TNF-α were lowest with no exposure, higher with moderate exposure, and highest with heavy exposure (P < 0.05). Plasma CRP showed insignificant difference between the two groups.
Conclusion: Passive smoking causes significant rise in plasma TNF-α and IL4 with a dose dependent effect among school pupils in Khartoum.

passive smoking, children, IL4, CRP, TNFa

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