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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 12, No. 2, 2012, pp. 198-203
Bioline Code: hs12033
Full paper language: English
Document type: Research Article
Document available free of charge

African Health Sciences, Vol. 12, No. 2, 2012, pp. 198-203

 en Hypoglycaemic activity of commelina africana check for this species in other resources and ageratum conyzoides check for this species in other resources in relation to their mineral composition
Agunbiade, O.S.; Ojezele, O.M.; Ojezele, J.O. & Ajayi, A.Y.


Background: Many plants with antidiabetic properties probably act in part through their content of fibre, vitamins, bioactive or mineral content
Objectives: This study investigated the mineral, proximate, phytochemical compositions and hypoglycaemic effect of Commelina africana check for this species in other resources and Ageratum conyzoides check for this species in other resources extracts in diabetic rats, and the likely relationship between this property and the mineral, proximate and phytochemical compositions of the plants .
Methods: The plants were subjected to mineral, proximate composition and phytochemical analysis. Attempt was made to see (if any) the relationship between the hypoglycaemic effect and the mineral, proximate compositions and phytochemistry of the plants. Alloxan-induced diabetic animals were administered 500mg/kg body weight aqueous extracts of the plants and glibenclamide as the reference hypoglycaemic agent.
Results: Aqueous extract of Ageratum conyzoides reduced fasting blood glucose of experimental animals by 39.1% while Commelina africana reduced the same by 78.0%. Alkaloids, cardenolides, saponins, and tannins were detected in both plants. Anthraquinones was absent in C. africana but a trace of it was detected in A. conyzoides. The hypoglycaemic effect of Commelina africana was comparable with the reference hypoglycaemic agent. Ageratum conyzoides showed comparably weaker hypoglycaemic effect than exhibited by reference hypoglycaemic agent. Comparatively, Commelina africana had higher mineral concentrations (except Na) than Ageratum conyzoides.
Conclusions: Plants’ extracts minerals (magnesium, potassium and iron) and bioactive components (alkaloids and cardenolides) seemingly enhanced their hypoglycaemic effect. Furthermore, these minerals, alkaloids and cardenolides could be helpful in ameliorating complications of diabetes like hypertension and cardiovascular disease.

Commelina africana, Ageratum conyzoides, diabetes

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