Many plants with antidiabetic properties probably act in part through their content of fibre, vitamins,
bioactive or mineral content
This study investigated the mineral, proximate, phytochemical compositions and hypoglycaemic effect of
and Ageratum conyzoides
extracts in diabetic rats, and the likely relationship between this property and the
mineral, proximate and phytochemical compositions of the plants .
The plants were subjected to mineral, proximate composition and phytochemical analysis. Attempt was made to
see (if any) the relationship between the hypoglycaemic effect and the mineral, proximate compositions and phytochemistry
of the plants. Alloxan-induced diabetic animals were administered 500mg/kg body weight aqueous extracts of the plants
and glibenclamide as the reference hypoglycaemic agent.
Aqueous extract of Ageratum conyzoides
reduced fasting blood glucose of experimental animals by 39.1% while
reduced the same by 78.0%. Alkaloids, cardenolides, saponins, and tannins were detected in both plants.
Anthraquinones was absent in C. africana
but a trace of it was detected in A. conyzoides.
The hypoglycaemic effect of
was comparable with the reference hypoglycaemic agent. Ageratum conyzoides
showed comparably weaker
hypoglycaemic effect than exhibited by reference hypoglycaemic agent. Comparatively, Commelina africana
had higher mineral
concentrations (except Na) than Ageratum conyzoides
Plants’ extracts minerals (magnesium, potassium and iron) and bioactive components (alkaloids and
cardenolides) seemingly enhanced their hypoglycaemic effect. Furthermore, these minerals, alkaloids and cardenolides could
be helpful in ameliorating complications of diabetes like hypertension and cardiovascular disease.