Hypoglycaemic effect of kolaviron (KV), (biflavonoid from Garcinia kola
) in streptozotocin (STZ)-diabetic
rats has been established.
To evaluate the possible protective effects of KV on cardiac, renal and hepatic tissues of STZ-diabetic rats.
This study consists of four groups of 6 rats each. Groups one and two contained non-diabetic and untreateddiabetic
rats, respectively. Groups three and four were made up of KV- and glibenclamide (GB) - treated diabetic rats,
STZ-intoxication caused a significant (p<0.05) increase in the relative weight of liver in diabetic rats. STZ-diabetic
rats had significant increase (p<0.05) in the levels of fasting blood glucose (FBG), á-amylase and HbA1c
. A marked and
significant (p<0.05) increase in the levels of cardiac, renal and liver marker indices such as serum creatine kinase, lactate
dehydrogenase, creatinine, urea and alanine aminotransferase were observed in untreated diabetic rats. Also, untreated
diabetic rats had significantly (p<0.05) elevated urinary glucose and protein and, lowered creatinine clearance. In KV- and
GB- treated groups, the levels of FBG, á-amylase and HbA1c
were significantly (p <0.05) reduced, while treatment with KV
significantly (p<0.05) attenuated the cardiac, renal and liver marker indices.
KV offered significant antidiabetic and tissues protective effects in the rats.