Background: Moringa stenopetala
, Baker f. (Moringaceae
) is used for food and medicine in Southern Ethiopia.
To substantiate the hypotensive effect of M. stenopetala in vivo
and in vitro
An in vivo
experiment was carried out on male guinea pigs anaesthetized with pentobarbital. The arterial blood
pressure was recorded from a carotid artery filled with heparinized saline via an arterial cannula connected to a pressure
transducer. For the in vitro
experiment the descending thoracic aorta was removed and kept moistened in Krebs-Henseleit
solution and then mounted in a 20ml tissue bath maintained at 370
C and bubbled with a mixture of 95% oxygen and 5%
Crude aqueous leaf extract of M. stenopetala
caused significant fall in systolic blood pressure (SBP), diastolic blood
pressure (DBP) and mean arterial blood pressure (MABP) at doses of 10, 20, 30 and 40 mg/kg in normotensive anaesthetized
guinea pigs (n = 12). The effect might have been mediated by non-autonomic nervous system as the effect is not altered by
atropine and propranolol. The extract also caused significant dose and time dependent inhibition of K+
on guinea pig aorta.
has blood pressure lowering effect substantiating the use of the plant in traditional medicine.