African Health Sciences
Makerere University Medical School
Vol. 13, No. 1, 2013, pp. 154-159
Bioline Code: hs13023
Full paper language: English
Document type: Research Article
Document available free of charge
African Health Sciences, Vol. 13, No. 1, 2013, pp. 154-159
© Copyright 2012 - African Health Sciences
Outcome of cholelithiasis in Sudanese children with Sickle Cell Anaemia (SCA) after 13 years follow-up|
Attalla, BAI; Karrar, ZA; Ibnouf, G; Mohamed, AO; Abdelwahab, O; Nasir E M & El Seed M A
Background:SCA causes chronic haemolysis which is a risk factor for cholelithiasis.
Objective:To determine the prevalence and outcome of children with SCA complicated with gallstones treated at the sickle
cell clinic at the children emergency hospital Khartoum state.
Methods:261 patients age 4 months to 16 years were studied. AUS examination was carried out. The 30 patients in whom
gall stones were detected followed prospectively from June 1996 to September 2009 when a second AUS examination was
Results:Gall stones occurred in 30 patients of whom four were lost to follow up in the first year. The overall prevalence of
cholelithiasis was 11.5% and it increased with age. The youngest patient with cholelithiasis was 2 1/2 years old. Haematological
variables, bilirubin and sex did not identify a subgroup of patients at higher risk for gallstones. All the patients were
asymptomatic at the time of diagnosis. One patient developed symptoms 3years after the diagnosis and he was submitted
to surgery. The 25 remaining asymptomatic patients were followed up for 13 years and none of them presented complications
related to cholelithiasis during this period.
Conclusion:The prevalence of cholelithiasis in Sudanese children and adolescents with SCA was significant. The large
majority patients remained asymptomatic over a long period.