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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 13, No. 2, 2013, pp. 430-440
Bioline Code: hs13061
Full paper language: English
Document type: Research Article
Document available free of charge

African Health Sciences, Vol. 13, No. 2, 2013, pp. 430-440

 en Association of anti-Chlamydia antibodies with ectopic pregnancy in Benin city, Nigeria: a case-control study
Agholor, K; Omo-Aghoja, L & Okonofua, F

Abstract

Background: Ectopic pregnancy remains a major public health problem especially in many developing countries where it is a significant contributor to pregnancy related morbidity and mortality
Objective: To determine the association between prior Chlamydia trachomatis check for this species in other resources infection and the risk of ectopic pregnancy.
Methods: A case-control study from two tertiary health care facilities in Benin City, Nigeria. Ninety eight women with ectopic pregnancy (cases) and another 98 women with uncomplicated intrauterine pregnancy (controls) matched for age, were interviewed using a semi-structured questionnaire and evaluated for serological evidence of prior Chlamydia trachomatis infection.
Results: The antibody titres in cases (48%) were significantly higher than in controls (16.3%) (p<0.001). However, the association between Chlamydia antibodies and ectopic pregnancy was attenuated when the effects of indicators of previous pelvic infections, socio-demographic characteristics, contraceptive and sexual history were controlled for. Primary level of education (OR = 6.32; CI, 2.31 – 17.3), three or more lifetime sexual partners (OR = 5.71; CI, 2.39 – 13.65) and prior history of vaginal discharge (OR = 5.00; CI, 2.03 – 12.3) were more likely to be associated with ectopic pregnancy than with the presence of antibodies to Chlamydia trachomatis (OR = 2.82; 95% CI, 1.33 – 5.95). The Population Attributable Risk was 30.9%.
Conclusion: Chlamydial infections play only a limited role in the pathogenesis of ectopic pregnancy.

Keywords
anti-chlamydia antibodies; ectopic pregnancy; sexual history; vaginal discharge; level of education

 
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