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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 13, No. 2, 2013, pp. 518-521
Bioline Code: hs13073
Full paper language: English
Document type: Case Report
Document available free of charge

African Health Sciences, Vol. 13, No. 2, 2013, pp. 518-521

 en Disseminated Histoplasmosis in a 13-year-old girl: a case report
Ubesie, A C; Okafo, O C; Ibeziako, N S; Onukwuli, V O; Mbanefo, N R; Uzoigwe, J C; Bede, C & Ibe, B C


Background: Disseminated histoplasmosis is a rare fungal infection and most documented cases are in immunecompromised individuals such as those with acquired immuno-deficiency syndrome.
Objective: To describe a case of disseminated histoplasmosis in an adolescent girl.
Method: We report a case of disseminated histoplasmosis in a 13-year-old adolescent girl. She was admitted for 16 days because of neck masses of 3 years duration, generalized body swelling of 3 months and reduction in urinary output of 2 months. She tested negative for human immunodeficiency virus antibodies.
Result: An autopsy was performed because a definitive diagnosis could not be made while the patient was still alive. The autopsy revealed central caseating areas in the lymph nodes and membranoproliferative glomerulonephritis. The periodic acid-Schiff staining technique for tissues showed viable yeast cells suggestive of histoplasmosis. Zeihl-Neelsen’s staining for mycobacteria tuberculosis was negative.
Conclusion: Undiagnosed case of disseminated histoplasmosis while the patient was alive is being reported in a 13-yearold girl. Disseminated histoplasmosis should be considered as a differential diagnosis of childhood chronic infections and malignancies as in Nigeria.

Disseminated histoplasmosis; immune-competent, adolescent girl, Enugu

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