search
for
 About Bioline  All Journals  Testimonials  Membership  News


African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 13, No. 2, 2013, pp. 529-540
Bioline Code: hs13079
Full paper language: English
Document type: Research Article
Document available free of charge

African Health Sciences, Vol. 13, No. 2, 2013, pp. 529-540

 en MRI findings in people with epilepsy and nodding syndrome in an area endemic for onchocerciasis: an observational study
Winkler, A S; Friedrich, K; Velicheti, S; Dharsee, J; König, R; Nassri, R; Meindl, M; Kidunda, A; Müller, T H & Jilek-Aall, L

Abstract

Background: Onchocerciasis has been implicated in the pathogenesis of epilepsy. The debate on a potential causal relationship between Onchocerca volvulus check for this species in other resources and epilepsy has taken a new direction in the light of the most recent epidemic of nodding syndrome.
Objective: To document MRI changes in people with different types of epilepsy and investigate whether there is an association with O. volvulus infection.
Methods: In a prospective study in southern Tanzania, an area endemic for O. volvulus with a high prevalence of epilepsy and nodding syndrome, we performed MRI on 32 people with epilepsy, 12 of which suffered from nodding syndrome. Polymerase chain reaction (PCR) of O. volvulus was performed in skin and CSF.
Results: The most frequent abnormalities seen on MRI was atrophy (twelve patients (37.5%)) followed by intraparenchymal pathologies such as changes in the hippocampus (nine patients (28.1%)), gliotic lesions (six patients (18.8%)) and subcortical signal abnormalities (three patients (9.4%)). There was an overall trend towards an association of intraparenchymal cerebral pathologies and infection with O. volvulus based on skin PCR (Fisher’s Exact Test p=0.067) which was most pronounced in children and adolescents with nodding syndrome compared to those with other types of epilepsy (Fisher’s Exact Test,p=0.083). Contrary to skin PCR results, PCR of CSF was negative in all patients.
Conclusion: The observed trend towards an association of intraparenchymal cerebral pathological results on MRI and a positive skin PCR for O. volvulus despite negative PCR of CSF is intriguing and deserves further attention.

Keywords
Epilepsy; head nodding; magnetic resonance imaging; cerebrospinal fluid; Onchocerca volvulus

 
© Copyright 2013 - African Health Sciences

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2023, Site last up-dated on 01-Sep-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil