About Bioline  All Journals  Testimonials  Membership  News

African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 13, No. 4, 2013, pp. 933-939
Bioline Code: hs13131
Full paper language: English
Document type: Research Article
Document available free of charge

African Health Sciences, Vol. 13, No. 4, 2013, pp. 933-939

 en In vivo hypoglycemic effect of methanolic fruit extract of Momordica charantia check for this species in other resources L
Nkambo, W.; Anyama, N.G. & Onegi, B.


Background: Momordica charantia check for this species in other resources is a medicinal plant commonly used in the management of diabetes mellitus.
Objectives: We investigated the blood glucose lowering effect of the methanolic fruit extract of the Ugandan variety of M.charantia L. in alloxan-induced diabetic albino rats.
Methods: 500g of M. charantia powder were macerated in methanol and the extract administered to two groups of alloxaninduced diabetic rats. The first group received 125mg/kg, the second 375mg/kg and a third group 7mg/ kg of metformin. A fourth group received 1ml normal saline. Fasting blood glucose (FBG) levels were measured at 0.5,1,2,3,5,8 and 12 hours and compared using one-way ANOVA.
Results: There was an initial rise in FBG for 1 hour after administration of extracts followed by steep reductions. Significant reduction in FBG occurred at 2 hours for 125mg/kg of extract (-3.2%, 313±25.9 to 303±25.0mg/dL, p = 0.049), 375mg/kg of extract (-3.9%, 356±19.7 to 342±20.3mg/dL, p = 0.001), and metformin (-2.6%, 344±21.7 to 335±21.1mg/dL, p =0.003) when compared to normal saline. The maximum percentage reduction in FBG by both extracts occurred between 3 and 12 hours post dose.
Conclusions:The methanolic fruit extract of M. charantia exhibits dose dependent hypoglycaemic activity in vivo

Momordica charantia; methanolic extract; Diabetes Mellitus; hypoglycaemic effect; in vivo

© Copyright 2013 - African Health Sciences

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2023, Site last up-dated on 01-Sep-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Google Cloud Platform, GCP, Brazil