African Health Sciences
Makerere University Medical School
Vol. 13, No. 4, 2013, pp. 955-961
Bioline Code: hs13134
Full paper language: English
Document type: Research Article
Document available free of charge
African Health Sciences, Vol. 13, No. 4, 2013, pp. 955-961
© Copyright 2013 - African Health Sciences
Seroprevalence of HBV and HIV co-infection in children and outcomes following highly active antiretroviral therapy (HAART) in Uyo, South-South Nigeria|
Ikpeme, E.E.; Etukudo, O.M. & Ekrikpo, U.E.
Background: Human Immunodeficiency Virus/ Hepatitis B Virus (HIV/HBV) co-infection in Nigerian children has emerged as a major concern with the advent of HAART. Its impact on the immune system and liver has not been extensively studied in children.
Objectives: To determine the prevalence of HBV seropositivity among HIV positive children on HAART and its effect on immune response and liver enzymes.
Methods: All consecutive HIV positive children aged two months to seventeen years on HAART constituted the study population. Age and gender; CD4+ count, ALT, creatinine and HBsAg were tested and documented at enrolment and 12months.
Results: One hundred and seventy one patients were seen over this period. Seventy-two (43.4%) were males while 94(56.6%) were females giving a male: female ratio of 1:1.3. The mean age of the patients was 63±43.4 months. Prevalence of HIV/HBV co-infection was 6.02% (95% CI 2.4-9.7). There was no significant effect of HBV status on elevation of ALT levels with 12 months of HAART. Co-infected patients had an odds ratio of achieving immune response of 0.14 (95% CI 0.02-0.79).
Conclusion: HIV/HBV co-infection rates in our children are comparable to other localities. ALT levels do not worsen with HAART and immune response of the co-infected children on HAART is lower.