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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 13, No. 4, 2013, pp. 970-976
Bioline Code: hs13136
Full paper language: English
Document type: Research Article
Document available free of charge

African Health Sciences, Vol. 13, No. 4, 2013, pp. 970-976

 en Synergistic effect of aqueous extract of Telfaria occidentalis check for this species in other resources on the biological activities of artesunate in Plasmodium berghei check for this species in other resources infected mice
Adegbolagun, O.M.; Emikpe, B.O.; Woranola, I.O. & Ogunremi, Y.


Background: Resistance to most antimalarial drugs has encouraged the use of herbal preparations along with prescribed orthodox drugs.
Objective: To investigate effect of co-administration of aqueous extract of T. occidentalis check for this species in other resources leaves; commonly used as antimalarial and haematinic agent in Nigeria and artesunate using P. berghei check for this species in other resources animal model.
Methods: In vivo curative antiplasmodial effect of T. occidentalis (200mg/kg) alone and combination with artesunate (2mg/kg) were evaluated using albino mice infected with 106 parasitized erythrocytes of P. berghei intraperitoneally. The haematological parameters: haemoglobin level, red blood cells and white blood cells and packed cell volume were monitored using standard methods.
Results: Aqueous extract of T. occidentalis, artesunate and the combination gave 72.17±4.07%, 70.43± 4.27% and 85.43±3.65% reduction in parasitaemia after 48hours respectively. A significant enhancement of the PCV was obtained with the coadministration of artesunate and aqueous extract (p< 0.01). Similar trends were also observed with heamatological parameters at 72hours of administration.
Conclusion: This study revealed a synergistic effect of the co-administration on parasite clearance rate of P. berghei infection in mice, with a significant enhancement of haematological parameters within 48 hours of administration. This indicates a rapid rate of recovery from plasmodial infections with the co-administration.

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