African Health Sciences
Makerere University Medical School
Vol. 14, No. 1, 2014, pp. 49-55
Bioline Code: hs14008
Full paper language: English
Document type: Research Article
Document available free of charge
African Health Sciences, Vol. 14, No. 1, 2014, pp. 49-55
© Copyright 2014 - African Health Sciences
Symptom clusters and quality of life in China patients with lung cancer undergoing chemotherapy|
Dandan, Wang & Jufang, Fu
Objective:To explore the symptom clusters and quality of life in patients with lung cancer undergoing chemotherapy.
Methods:A cross-sectional survey was completed with 183 patients from three public hospitals in Xi’an, China. Patients
completed a demographic questionnaire, the Functional Assessment of Cancer Therapy-Lung Cancer (FACT-L) and the M.
D. Anderson Symptom Inventory (MDASI-C). Factor analysis was used to identify symptom clusters based on the severity
of patients’ symptom experiences. The resulting clusters were correlated with quality-of-life measures.
Results:The QOL scores of lung cancer patients on the functioning subscale were the lowest (9.70±5.30), while those of
the family subscale were the highest (19.28±3.24). Three symptom clusters were identified: gastrointestinal, emotional and
fatigue–related symptoms. There was a negative relationship between the symptom clusters and multiple dimensions of
quality of life (r -0.178～-0.805, p< 0. 05). Females, especially those women with low education level /chronic diseases, were
experienced greater symptom distress than others.
Conclusions:The clusters had a negative relationship with QOL. Identifying symptom clusters helped clarify possible inter-relationships which may lead to the establishment of more effective symptom management interventions for patients with
lung cancer in order to improve the quality of life.
symptom clusters; lung cancer; factor analysis; symptom management; quality of life