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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 14, No. 1, 2014, pp. 201-205
Bioline Code: hs14031
Full paper language: English
Document type: Review Article
Document available free of charge

African Health Sciences, Vol. 14, No. 1, 2014, pp. 201-205

 en Review of the chemistry and pharmacology of 7-Methyljugulone
Armelle, T. Mbaveng & Victor, Kuete


Background:Naphthoquinone is a class of phenolic compounds derived from naphthalene. 7-Methyljuglone (7-MJ) is a naphthoquinone also known as ramentaceone or 6-Methyl-8-hydroxy-1,4-naphthoquinone or 5-Hydroxy-7-methyl-1,4-naphthoquinone or 7-Methyl-5-hydroxy-1,4-naphthoquinone or 5-Hydroxy-7-methyl-,1,4-naphtoquinone or 7-Methyl-5-hydroxynaphthalene-1,4-dione. This compound is a biologically active naphtoquinone, with a molecular weight of 188 g/ mol mostly isolated in the genus Diospyros and Euclea.
Objectives:This review was aimed at providing available chemically and pharmacological data on 7-MJ. Methods:The chemical and pharmacological data were retrieved from the well-known scientific websites such as Pubmed, Google Scholar, Reaxys, Scirus, Scopus, Sciencedirect, Web-of-knowledge and Scifinder.
Results:7-MJ was reported to have a variety of pharmacological activities such as antibacterial, antifungal, anticancer, antitubercular, anti-inflammatory and antiviral activities. The hemi-synthesis of the compound have been described.
Conclusions:The present review pooled out together the knowledge on 7-MJ, and can serve as the start point for future research and valorization accomplishments.

7-methyljugulone; biosynthesis; in vitro synthesis; pharmacology

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