Review of the chemistry and pharmacology of 7-Methyljugulone|
Armelle, T. Mbaveng & Victor, Kuete
Background:Naphthoquinone is a class of phenolic compounds derived from naphthalene. 7-Methyljuglone (7-MJ) is
a naphthoquinone also known as ramentaceone or 6-Methyl-8-hydroxy-1,4-naphthoquinone or 5-Hydroxy-7-methyl-1,4-naphthoquinone or 7-Methyl-5-hydroxy-1,4-naphthoquinone or 5-Hydroxy-7-methyl-,1,4-naphtoquinone or 7-Methyl-5-hydroxynaphthalene-1,4-dione. This compound is a biologically active naphtoquinone, with a molecular weight of 188 g/
mol mostly isolated in the genus Diospyros and Euclea.
Objectives:This review was aimed at providing available chemically and pharmacological data on 7-MJ.
Methods:The chemical and pharmacological data were retrieved from the well-known scientific websites such as Pubmed,
Google Scholar, Reaxys, Scirus, Scopus, Sciencedirect, Web-of-knowledge and Scifinder.
Results:7-MJ was reported to have a variety of pharmacological activities such as antibacterial, antifungal, anticancer,
antitubercular, anti-inflammatory and antiviral activities. The hemi-synthesis of the compound have been described.
Conclusions:The present review pooled out together the knowledge on 7-MJ, and can serve as the start point for future
research and valorization accomplishments.
7-methyljugulone; biosynthesis; in vitro synthesis; pharmacology