African Health Sciences
Makerere University Medical School
Vol. 14, No. 1, 2014, pp. 206-210
Bioline Code: hs14032
Full paper language: English
Document type: Research Article
Document available free of charge
African Health Sciences, Vol. 14, No. 1, 2014, pp. 206-210
© Copyright 2014 - African Health Sciences
The influence of bile acids homeostasis by cryptotanshinone-containing herbs|
Chengcheng, Gao; Tianheng, Ma; Liqun, Pang & Rui, Xie
Background: Herbs might affect the homeostasis of bile acids through influence of multiple metabolic pathways of bile
Objective:To investigate the inhibition of cryptotanshinone towards the glucuronidation of LCA, trying to indicate the
possible influence of cryptotanshinone-containing herbs towards the homeostasis of bile acids.
Methods:The LCA-3-glucuronidation and LCA-24-glucuronidation reaction was monitored by LC-MS.
Results:Initial screening showed that 100 μM of cryptotanshinone inhibited LCA-24-glucuronidation and LCA-3-glucuro-nidation reaction activity by 82.6% and 79.1%, respectively. This kind of inhibition behaviour exerted cryptotanshinone
concentrations-dependent and LCA concentrations-independent inhibition behaviour.
Conclusion: All these data indicated the possibility of cryptotanshinone’s influence towards bile acids metabolism and
homeostasis of bile acids.
herbs; lithocholic acid (LCA); homeostasis