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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 14, No. 1, 2014, pp. 206-210
Bioline Code: hs14032
Full paper language: English
Document type: Research Article
Document available free of charge

African Health Sciences, Vol. 14, No. 1, 2014, pp. 206-210

 en The influence of bile acids homeostasis by cryptotanshinone-containing herbs
Chengcheng, Gao; Tianheng, Ma; Liqun, Pang & Rui, Xie


Background: Herbs might affect the homeostasis of bile acids through influence of multiple metabolic pathways of bile acids.
Objective:To investigate the inhibition of cryptotanshinone towards the glucuronidation of LCA, trying to indicate the possible influence of cryptotanshinone-containing herbs towards the homeostasis of bile acids.
Methods:The LCA-3-glucuronidation and LCA-24-glucuronidation reaction was monitored by LC-MS.
Results:Initial screening showed that 100 μM of cryptotanshinone inhibited LCA-24-glucuronidation and LCA-3-glucuro-nidation reaction activity by 82.6% and 79.1%, respectively. This kind of inhibition behaviour exerted cryptotanshinone concentrations-dependent and LCA concentrations-independent inhibition behaviour.
Conclusion: All these data indicated the possibility of cryptotanshinone’s influence towards bile acids metabolism and homeostasis of bile acids.

herbs; lithocholic acid (LCA); homeostasis

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