African Health Sciences
Makerere University Medical School
Vol. 14, No. 3, 2014, pp. 763-768
Bioline Code: hs14113
Full paper language: English
Document type: Research Article
Document available free of charge
African Health Sciences, Vol. 14, No. 3, 2014, pp. 763-768
© Copyright 2014 - African Health Sciences
Coats’ disease in Tanzania: first case report and literature review|
Rugwizangoga, Belson; Mwabili, Theresia; Meyer, Peter & Kitinya, James
Coats’ disease is an exudative retinal detachment with vascular telangiectasis occurring mostly in male children, the age group most affected by retinoblastoma.
To compare the differential diagnoses of Coats’ disease
To establish recommendation to early disease detection.
Materials and Methods:
A 3-year-old female child was referred to Muhimbili National Hospital (MNH), Tanzania, in September 2011. She had presented at the peripheral hospital with gradual onset of left eye leukocoria for 1 year and pain for 2 months. B-scan showed a mass in the left eye. A clinical diagnosis of retinoblastoma was made. Left eye enucleation was performed; the patient was referred to MNH, with the enucleated specimen.
Brain and orbits scan revealed no residual tumour. The globe measured 2x1.8 cm, the optic nerve stump measured 3 mm. A whitish mass filled the vitreous, with complete retinal detachment. Microscopy showed retinal gliosis, detachment with sub retinal PAS positive exudates, vacuolation and cholesterol clefts. Foreign body giant cells were present; telangiectatic thin-walled blood vessels were identified. Clinico-pathological findings were of stage 4 Coats’ disease.
Coats’ disease is an important differential diagnosis of retinoblastoma. Delay to detect Coats’ disease leads to vision loss which necessitates eye enucleation as was in this child.
Coats’ disease; Tanzania