A retrospective evaluation of critically ill patients infected with H1N1 influenza A virus in Bursa, Turkey, during the 2009–2010 pandemic|
Nermin, Kelebek Girgin; Remzi, Iscimen; Zeynep, Akogul; Ilker, Cimen; Meltem, Oner Torlar; Guven, Ozkaya; Ferda, Kahveci & Halis, Akalin
Background: H1N1 influenza A virus infections were first reported in April 2009 and spread rapidly, resulting in mortality
worldwide. The aim of this study was to evaluate patients with H1N1 infection treated in the intensive care unit (ICU) in
Methods: Demographic characteristics, clinical features, and outcome relating to H1N1 infection were retrospectively analysed
in patients treated in the ICU.
Results: Twenty-three cases of H1N1 infection were treated in the ICU. The mean age of patients was 37 years range: (17–
82). Fifteen patients were female (65.2%). The mean Acute Physiology and Chronic Health Evaluation (APACHE) II score
was 19 range: (5–39). The most common symptoms were dyspnea (73.9%), fever (69.6%), and cough (60.9%). Mechanical
ventilation was required for all patients. Oseltamivir and antibiotics were administered to all patients. Six (26.1%) patients
died. APACHE II scores were higher in the deceased 28.5 range: [16–39] vs. 14 range: [5–28] in survivors; p = 0.013).
Conclusion: When compared to the literature, the demographic, epidemiological, and clinical characteristics were similar
in the cases we encountered. The mortality rate was high despite the use of appropriate treatment. We believe that the high
mortality is related to higher APACHE II scores. The H1N1 virus should be considered in community acquired pneumonia,
especially in younger patients presenting with severe pneumonia.
pandemic influenza; H1N1 infection; critically ill patient; intensive care unit