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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 15, No. 2, 2015, pp. 606-612
Bioline Code: hs15084
Full paper language: English
Document type: Research Article
Document available free of charge

African Health Sciences, Vol. 15, No. 2, 2015, pp. 606-612

 en Comparative study on the effects of aqueous extracts of viscum album check for this species in other resources (mistletoe) from three host plants on hematological parameters in albino rats.
Ladokun, Olusola; Ojezele, Matthew & Arojojoye, Oluwatosin


Background: The extract of the leaves of viscum album check for this species in other resources (mistletoe) has been used for centuries in traditional medicine in many parts of the world. However, like many medicinal plants, the belief that things of natural origin are safe may not be entirely true. The blood is a good indicator of health and pathological mirror of the entire body.
Objective: Therefore, in this study, the acute effects of extracts of mistletoe, harvested from three hosts, on haematology indices of wistar albino rats was investigated.
Methods: Graded doses (400, 800, 1600 and 3200mg/kg body weight) of aqueous extracts of mistletoe from three different host plants, coffee (Coffee arabica), kola (Kola nitida), cocoa (Theobromae cacao), were administered orally to wistar albino rats for 14 days. Full haematological parameters were evaluated on whole blood collected from rats twenty four hours after the administration of the last dose.
Results: Mistletoe from kola caused a concentration dependent and statistically significant (p<0.05) reduction in platelets count in rats. Administration of mistletoe extract from cocoa and coffee led to reduction in hemoglobin concentration. Reductions in packed cell volume (PCV) and red blood cell (RBC) and increase in white blood cells (WBC) were also observed in rats administered all the extracts.
Conclusion: Increase in the WBC count observed in rats administered mistletoe suggests that mistletoe extract contains agents that could stimulate the production of leucocytes and could serve as immune booster. However, there is need to be cautious in administration at high doses to prevent the risk of anaemia.

Viscum album; coffee arabica; kola nitida; theobromae cacao; haematology

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