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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 15, No. 2, 2015, pp. 613-620
Bioline Code: hs15085
Full paper language: English
Document type: Research Article
Document available free of charge

African Health Sciences, Vol. 15, No. 2, 2015, pp. 613-620

 en Anti-inflammatory and antioxidant properties of Eriobotrya japonica check for this species in other resources leaves extracts
Maher, Kammoun; Yassine, Ben Ali & Sofiane, Bezzine


Background: In the present work we determined phenolic and flavonoids content of Eriobotrya japonica check for this species in other resources leaves extracts and fractions and their antioxidant and anti-inflammatory properties.
Objectives: To evaluate the inhibition of inflammatory PLA2 and antioxidant effects of extracts and fractions from Eriobotrya japonica leaves
Methods: Antioxidant activity was evaluated with DPPH radical scavenging assay and anti-inflammatory effect of fractions was measured by their inhibition potency on the human pro-inflammatory phospholipase A2 (group IIA).
Results: The EtOH/EtOAc 2:1 extract exhibited a potent inhibition of the hG-IIA with an IC50 values of 8 μg/ml. It also shows an antioxidant activity measured on DPPH with an IC50 of 42 μg/ml. Fractionation shows that CH2Cl2/MeOH 0:1 fraction was the rich one on flavonoids compounds (4.3 mg/g dry weight) and demonstrates a high antioxidant activity with an IC50 of 12 μg/ml. The anti-inflammatory evaluation demonstrates that the same fraction was the best one to inhibit the pro-inflammatory phospholipase A2 group IIA with an IC50 of 4 μg/ml.
Conclusion: Study conducted on Eriobotrya japonica shows that CH2Cl2/MeOH 0:1 fraction inhibits efficiently the hGIIA phospholipase.which is considered as pro-inflammatory enzyme.

Eriobotrya japonica; extraction; flavonoids; anti-inflammatory

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