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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 15, No. 3, 2015, pp. 714-718
Bioline Code: hs15100
Full paper language: English
Document type: Research Article
Document available free of charge

African Health Sciences, Vol. 15, No. 3, 2015, pp. 714-718

 en Chronic hepatitis B associated with hepatic steatosis, insulin resistance, necroinflammation and fibrosis.
Yilmaz, Bulent; Koklu, Seyfettin; Buyukbayram, Huseyin; Yalçin, Kendal; Korkmaz, Ugur; Posul, Emrah; Can, Guray & Kurt, Mevlut


Background: The effect of hepatitis B virus (HBV) infection on fatty liver disease is unclear..
Objectives: The aim of this study was to investigate the viral and host causes of fatty liver in chronic hepatitis B (CHB) patients. This study included 88 CHB patients of which 17 were not treated. Liver biopsy was performed in each patient. Group 1 included those with hepatic steatosis (n=28) and group 2 those without hepatic steatosis. The groups were compared in terms of age, body mass index (BMI), Homeostasis Model Assessment- Insulin Resistance (HOMA-IR), viral load, biochemical parameters and histological findings. Patients in group 1 were subdivided according to the degree of steatosis as follows: grade 1 (15 patients, 53.6%), grade 2 (6 patients, 21.4%),and grade 3 (7 patients, 25%).
Results: In group 1 (n=28), mean age, BMI, cholesterol, and HOMA-IR were found to be significantly higher than in group 2 (n=60). There were no significant differences in the positivity of viral load, HbeAg, treatment, fibrosis and other laboratory parameters between the two groups. HOMA-IR was the only independent predictive factor of liver steatosis in patients with CHB in logistic regression analysis.
Conclusion: Hepatic steatosis in CHB patients was associated with host metabolic factors.

Chronic hepatitis B, liver steatosis, HOMA-IR, BMI, biopsy

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