African Health Sciences
Makerere University Medical School
Vol. 15, No. 3, 2015, pp. 828-834
Bioline Code: hs15114
Full paper language: English
Document type: Research Article
Document available free of charge
African Health Sciences, Vol. 15, No. 3, 2015, pp. 828-834
© Copyright 2015 - African Health Sciences
Variations in antimalarial components of Artemisia annua Linn from three regions of Uganda|
Ogwang Engeu, Patrick; Omujall, Francis; Moses, Agwaya; Kyakulaga, Hassan & Obua, Celestino
Introduction: Artemisia annua plant from the family Asteracea is a powerful antimalarial plant introduced to Uganda
around 2003. In addition to the artemisinin component, the plant also contains flavonoids which work in synergy to artemisinin
against malaria parasites. The plant also contains aromatic oils which repel mosquitoes. In this paper we report the
variations in antimalarial components of A. annua samples from the regions cultivating it in Uganda.
Methods: Artemisia annua samples were obtained from three regions that cultivated the plant at the time of this study. The
samples were brought to laboratory, authenticated and processed. The levels of artemisinin, total flavonoids and aromatic
components were quantified using high performance thin layer chromatography, ultra violet spectrophotometry and gas
Results: Artemisinin and total flavonoids levels were higher in samples obtained from high land areas (western and south
western region) compared to that obtained from lowland regions (central) i.e 0.8% Vs 0.4% and 2.6% Vs 1.5% respectively.
The aromatic oils (mosquito repellent components) were similar with camphor component being highest and levels ranging
from 75.4% to 79.0%.
Conclusion: Our findings show that the active components in Artemisia annua cultivated and used in the Uganda vary with
geographical regions and this calls for standardisation by source.
Variations, Antimalarial components, Artemisia annua, Uganda