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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 15, No. 3, 2015, pp. 835-840
Bioline Code: hs15115
Full paper language: English
Document type: Research Article
Document available free of charge

African Health Sciences, Vol. 15, No. 3, 2015, pp. 835-840

 en Antiplasmodial activity of some phenolic compounds from Cameroonians Allanblackia
Azebaze, Anatole Guy Blaise; Teinkela, Jean Emmanuel Mbosso; Nguemfo, Edwige Laure; Valentin, Alexis; Dongmo, Alain Bertrand & Vardamides, Juliette Cathérine


Background: Plasmodium falciparum, one of the causative agents of malaria, has high adaptability through mutation and is resistant to many types of anti-malarial drugs. This study presents an in vitro assessment of the antiplasmodial activity of some phenolic compounds isolated from plants of the genus Allanblackia check for this species in other resources .
Methods: Tests were performed on well plates filled with a fixed parasitized erythrocytes volume. Compounds to be tested were then added in wells. After incubation, tritiated hypoxanthine is added and the plates were returned to the incubator. After thawing, the nucleic acids are collected. Inhibitory Concentration 50 (IC50) was determined by linear interpolation.
Results: From Allanblackia floribunda check for this species in other resources , have been isolated and characterized 1,7-dihydroxyxanthone 1, macluraxanthone 4, morelloflavone 9, Volkensiflavone 10 and morelloflavone 7-O-glucoside 11; from Allanblackia monticola, α-mangosine 2, rubraxanthone 3, allaxanthone C 5, norcowanine 6 , tovophiline A 7, allaxanthone B 8 and from Allanblackia gabonensis check for this species in other resources , 1,7-dihydroxyxanthone 1. Six of them were evaluated for their antimalarial properties. The most active compound, macluraxanthone, presented a very interesting activity, with an IC50 of 0.36 and 0.27 μg/mL with the F32 and FcM29 strains respectively.
Conclusion: This work confirms that species of Allanblackia genus are medicinally important plants containing many biologically active compounds that can be used effectively as antiplasmodial.

Guttiferaceae, Allanblackia, Phenolic compounds, Antiplasmodial activity

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