African Health Sciences
Makerere University Medical School
Vol. 15, No. 3, 2015, pp. 841-850
Bioline Code: hs15116
Full paper language: English
Document type: Research Article
Document available free of charge
African Health Sciences, Vol. 15, No. 3, 2015, pp. 841-850
© Copyright 2015 - African Health Sciences
Potential antimalarial activity of Methyl Jasmonate and its effect on lipid profiles in Plasmodium Berghei infected mice|
Oyinloye, Oladapo E.; Kosoko, Ayokulehin M.; Benjamin, Emikpe; Falade, Catherine O. & Ademowo, Olusegun G.
Background: The antimalarial activity and lipid profiles of Methyl Jasmonate (MJ) were investigated against established
malaria infection in vivo using BALB/c mice.
Methods: Arteether (AE) and chloroquine (CQ) were used as reference drugs while ethanol was used as the vehicle for drug
delivery for MJ.
Results: Mice treated with 10 and 25 mg/kg MJ showed a remarkable reduction in percentage parasitemia by 68.3% and
78.2% on day 10(post treatment) respectively while 45.4% and 87.2% reduction in percentage parasitemia were observed
in the group treated with 50 mg/kg on day 3 and 10 ( post treatment ) respectively. The highest mean survival time was observed
in CQ followed by AE and MJ in dose-dependent manner. A progressive decrease in packed cell volume (PCV) was
observed in infected untreated mice which led to the death of all the mice by day 9 (post treatment). Infected mice treated
with MJ showed reduced level of HDL and LDL compared with infected untreated group. As the dose of MJ increased in
infected mice cholesterol levels increased while there was reduction in triglyceride.
Conclusion: Overall there was marked decrease in parasitemia in Plasmodium berghei infected mice treated with graded
doses of MJ but appears to have reduced antimalarial activity compared with CQ and AE.
Antimalarial activity, Lipid profile, Mice, Methyl jasmonate, Plasmodium berghei