Nasal carriage of Staphylococcus aureus
is becoming an increasing problem among healthcare workers and
To determine the prevalence of methicillin-resistant S. aureus
(MRSA) nasal colonization and inducible clindamycin
resistance (ICR) of S. aureus
among healthcare workers at Soba University Hospital and community members in
Khartoum State, Sudan.
Five hundred nasal swabs samples were collected during March 2009 to April 2010. Isolates were identified using
conventional laboratory assays and MRSA determined by the disk diffusion method. The D-test was performed for detection
of ICR isolates with Clinical Laboratory Standard Institute guidelines.
Of the 114 S. aureus
isolated, 20.2% represented MRSA. The occurrence of MRSA was significantly higher among
healthcare worker than community individuals [32.7% (18/55) vs. 6.9% (5/59)] (p=0.001). Overall the 114 S. aureus isolates
tested for ICR by D-test, 29 (25.4%) yielded inducible resistance. Significantly higher (p=0.026) ICR was detected among
MRSA (43.5%) than methicillin-susceptible S. aureus
MRSA nasal carriage among healthcare workers needs infection control practice in hospitals to prevent transmission
of MRSA. The occurrence of ICR in S. aureus
is of a great concern, D- test should be carried out routinely in our
hospitals to avoid therapeutic failure.