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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 15, No. 3, 2015, pp. 861-867
Bioline Code: hs15118
Full paper language: English
Document type: Research Article
Document available free of charge

African Health Sciences, Vol. 15, No. 3, 2015, pp. 861-867

 en Inducible clindamycin resistance and nasal carriage rates of Staphylococcus aureus among healthcare workers and community members.
Mahmoud, Alaa M.; Albadawy, Hanaa S.; Bolis, Samira M.; Bilal, Naser E.; Ahmed, Abdalla O. & Ibrahim, Mutasim E.


Background: Nasal carriage of Staphylococcus aureus check for this species in other resources is becoming an increasing problem among healthcare workers and community individuals
Objectives: To determine the prevalence of methicillin-resistant S. aureus (MRSA) nasal colonization and inducible clindamycin resistance (ICR) of S. aureus among healthcare workers at Soba University Hospital and community members in Khartoum State, Sudan.
Methods: Five hundred nasal swabs samples were collected during March 2009 to April 2010. Isolates were identified using conventional laboratory assays and MRSA determined by the disk diffusion method. The D-test was performed for detection of ICR isolates with Clinical Laboratory Standard Institute guidelines.
Results: Of the 114 S. aureus isolated, 20.2% represented MRSA. The occurrence of MRSA was significantly higher among healthcare worker than community individuals [32.7% (18/55) vs. 6.9% (5/59)] (p=0.001). Overall the 114 S. aureus isolates tested for ICR by D-test, 29 (25.4%) yielded inducible resistance. Significantly higher (p=0.026) ICR was detected among MRSA (43.5%) than methicillin-susceptible S. aureus (MSSA) (20.9%).
Conclusion: MRSA nasal carriage among healthcare workers needs infection control practice in hospitals to prevent transmission of MRSA. The occurrence of ICR in S. aureus is of a great concern, D- test should be carried out routinely in our hospitals to avoid therapeutic failure.

S. aureus nasal carriage, healthcare workers, community members, inducible clindamycin resistance

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