African Health Sciences
Makerere University Medical School
Vol. 15, No. 3, 2015, pp. 949-958
Bioline Code: hs15129
Full paper language: English
Document type: Research Article
Document available free of charge
African Health Sciences, Vol. 15, No. 3, 2015, pp. 949-958
© Copyright 2015 - African Health Sciences
Sonographic evaluation of the spleen among sickle cell disease patients in a teaching hospital in Nigeria.|
Eze, Charles Ugwoke; Offordile, Godfrey Chukwudi; Agwuna, Kennedy Kenechukwu; Ocheni, Sunday; Nwadike, Inoccent Uchechukwu & Chukwu, Bartholomew Friday
Background: Regional variations in size and parenchyma echo-texture of the spleen among sickle cell disease (SCD) patients
have been documented in various publications. The objectives of this study were to assess the size and parenchyma
echo-texture of the spleen of SCD patients and ascertain the relationship of age, height and weight with the spleen sizes.
Methods: This was a cross sectional study involving 103 each of SCD and age matched control subjects. Aloka ST- 550 -
3500 ultrasound machine with 3.5 and 5 MHz convex transducers was used to scan the subjects over a 15 months period
(September, 2012 to November, 2013). The age, height and weight of each subject were recorded.
Results: The spleen sizes of SCD patients were generally larger than those of the controls (p < 0.05). Abnormal spleen
parenchyma of varied appearances was found among the SCD subjects. There were negative correlations between mean
spleen sizes and height, weight and age in SCD patients but positive correlations were found between them in the controls.
Conclusion: Routine sonographic assessment of spleen size and echo-texture is useful in the management of SCD patients.
sickle cell disease, sonography, spleen morphology, patient management, Nigerian population