African Health Sciences
Makerere University Medical School
Vol. 15, No. 4, 2015, pp. 1232-1238
Bioline Code: hs15169
Full paper language: English
Document type: Research Article
Document available free of charge
African Health Sciences, Vol. 15, No. 4, 2015, pp. 1232-1238
© Copyright 2015 - African Health Sciences
Clinical and genetic data of Huntington disease in Moroccan patients|
Bouhouche, Ahmed; Regragui, Wafaa; Lamghari, Hind; Khaldi, Khadija; Birouk, Nazha; Lytim, Safaa; Bellamine, Soufiane; Kriouile, Yamna; Bouslam, Naima; Ben Haddou, El Hachmia Ait; Faris, Mustapha Alaoui; Benomar, Ali & Yahyaoui, Mohamed
Background: Huntington's disease (HD) occurs worldwide with prevalence varying from 0.1 to 10 /100,000 depending of
the ethnic origin. Since no data is available in the Maghreb population, the aim of this study is to describe clinical and genetic
characteristics of Huntington patients of Moroccan origin.
Methods: Clinical and genetics data of 21 consecutive patients recruited from 2009 to 2014 from the outpatient clinic of
six medical centers were analyzed. Statistical analysis was performed using descriptive statistics.
Results: Twenty one patients from 17 families were diagnosed positive for the IT15 gene CAG expansion. Clinical symptoms
were predominantly motor (19/21). Twelve patients had psychiatric and behavioral disorders, and 11 patients had
cognitive disorders essentially of memory impairment. Analysis of genetic results showed that 5 patients had reduced penetrant
(RP) alleles and 16 had fully penetrant (FP) alleles. The mean CAG repeat length in patients with RP alleles was 38.4
± 0.54, and 45.37 ± 8.30 in FP alleles. The age of onset and the size of the CAG repeat length showed significant inverse
correlation (p <0.001, r = -0.754).
Conclusion: Clinical and genetic data of Moroccan patients are similar to those of Caucasian populations previously reported
in the literature.
Huntington disease/diagnosis; Huntington disease/epidemiology; Huntington disease/genetics; Trinucleotide repeat expansion