Background: Lonicera japonica
has been studied extensively by scholars at home and abroad, a number of compounds
have been isolated from it, which mainly include organic acids and flavonoids. Pharmacological studies have shown that
Lonicera japonica has antibacterial and gall bladder-protective effects.
Objective: To study the active constituents in
Lonicera japonica and the mechanism of their anti-upper respiratory tract
infection action in children.
Methods: Compounds were identified by chromatographic methods, and the mechanism of anti-pediatric upper respiratory
tract infection action of
Lonicera japonica decoction was studied using experimental animals.
Results: A total of four compounds were isolated, after injection of egg white, toe edema in rats in the control group was
very obvious, different test concentrations of
Lonicera japonica decoction all inhibited toe edema in rats to some extents,
the edema was the mildest in the
Lonicera japonica decoction high-dose group, which had the strongest inhibitory effect on
the development of inflammation, the
Lonicera japonica decoction showed certain dose-effect relationship with toe edema
in rats. In the rat body temperature control experiment, while body temperature of rats in the blank group had already risen,
other groups were still able to lower the body temperature of rats under the action of test drugs. The severity of ear edema
in mice in the blank control group was obvious, with increased thickness which showed significant difference between left
and right ears. Under test doses, three
Lonicera japonica decoction groups all inhibited xylene-induced ear edema in mice.
Conclusion: Lonicera japonica has an anti-upper respiratory tract infection action in children.
