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Levels of vitamin D receptor and CYP24A1 in patients with end-stage renal disease.
Ye, Jia-Jun; Zhou, Tian-Biao; Zhang, Yun-Fang; Wang, Qi; Su, Yan-Yan; Tang, Jia-Min & Li, Hong-Yan
Abstract
Objective: This study was performed to detect the expression of vitamin D receptor (VDR) and cytochrome P450, family 24,
subfamily A, polypeptide 1 (CYP24A1) in 24 end stage renal disease (ESRD) patients and 24 healthy controls.
Method: In this study, 24 ESRD patients and 24 healthy controls were included.
Results: In our study, the levels of VDR in patients with ESRD were reduced when compared with those from healthy controls
(5.20±0.32 vs 8.59±1.03; P﹤0.01). However, the levels of CYP24A1 in ESRD patients were increased than those from
healthy controls (50.18±21 vs 7.78±1.31; P﹤0.01). Correlation analysis showed that VDR levels were negatively correlated with
CYP24A1 (r=-0.723; P﹤0.01).
Conclusion: VDR levels were reduced and CYP24A1 levels were increased in patients with ESRD, and VDR levels were negatively
correlated with CYP24A1.
Keywords
Vitamin D receptor (VDR); CYP24A1; end-stage renal disease (ESRD)
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