African Health Sciences
Makerere University Medical School
Vol. 16, No. 3, 2016, pp. 750-754
Bioline Code: hs16095
Full paper language: English
Document type: Study
Document available free of charge
African Health Sciences, Vol. 16, No. 3, 2016, pp. 750-754
© Copyright 2016 - African Health Sciences
Histologic response after neoadjuvant chemoradiotherapy in locally advanced rectal adenocarcinoma: experience from Sudan.|
Abdalla,Ahmed Abd Elrahman; Alawad,Awad Ali M. & Ali,Hussein Abdalla M.
Background: Locally advanced rectal cancer can be down staged by neoadjuvant therapy and the resultant tumor response can
be quantified histologically. This study aimed to assess pathological response of neoadjuvant chemoradiation in patients with
locally advanced rectal cancers treated in Wad Medani Teaching Hospital (WMTH) and National Cancer Institute (NCI), Wad
Patients and Methods: A total of 36 consecutive patients with locally advanced rectal cancer that were managed in WMTH and
NCI during the period from 2006-2011 were reviewed. Preoperative pelvic radiotherapy was delivered. Total of 46 Gray were
delivered concurrently with 5- fluorouracil (5-FU) on the first and last week of radiation. Total mesorectal excision of the rectal
tumour either by anterior or abdominoperineal resections was planned at 6-8 weeks from completion of preoperative treatment.
The pathological response to therapy was assessed by histopathology examination of the surgical specimen.
Results: Initial clinical staging of patients revealed 58.3% of them were stage T3/T4N2M0 and 41.7% were stage T3N0M0.
Down-staging to stage T1/T2N0M0 was found in 36.1% and stage T3N0M0 in 30.6%. No response was seen in 8.3% of cases
with stage T3/T4N2M0 while complete clinical response (no residual) was seen in 25.0%. Complete histological response was
observed in 13.8%. Positive lymph-nodes metastasis was confirmed in 8.3% of cases.
Conclusion: Neoadjuvant chemoradiation is a reasonable option for cases of rectal cancer and deserves further evaluation.
Neoadjuvant; rectal cancer; chemoradiation; pathological response