African Health Sciences
Makerere University Medical School
Vol. 16, No. 3, 2016, pp. 755-765
Bioline Code: hs16096
Full paper language: English
Document type: Research Article
Document available free of charge
African Health Sciences, Vol. 16, No. 3, 2016, pp. 755-765
© Copyright 2016 - African Health Sciences
Left ventricular systolic function in sickle cell anaemia: an echocardiographic evaluation in adult Nigerian patients.|
Ejim,Emmanuel & Oguanobi,Nelson
Background: Reliable diagnostic measures for the evaluation of left ventricular systolic performance in the setting of altered
myocardial loading characteristics in sickle cell anaemia remains unresolved.
Objective: The study was designed to assess left ventricular systolic function in adult sickle cell patients using non-invasive endsystolic
stress – end-systolic volume index ratio.
Methods: A descriptive cross sectional comparative study was done using 52 patients recruited at the adult sickle cell anaemia
clinic of the University of Nigeria Teaching Hospital Enugu. An equal number of age and sex-matched healthy volunteers
served as controls. All the participants had haematocrit estimation, haemoglobin electrophoresis, as well as echocardiographic
Result: The mean age of the patients and controls were 23.93 ± 5.28 (range 18-42) and 24.17 ± 4.39 (range 19 -42) years respectively,
(t = 0.262; p= .794). No significant difference was seen in estimate of fractional shortening, and ejection fraction. The
cardiac out-put, cardiac index and velocity of circumferential shortening were all significantly increased in the cases compared
with the controls. The end systolic stress – end systolic volume index ratio (ESS/ESVI) was significantly lower in cases than
controls. There were strong positive correlation between the ejection phase indices (ejection fraction and fractional shortening)
and end systolic stress and ESS/ESVI.
Conclusion: The study findings suggest the presence of left ventricular systolic dysfunction in adult sickle cell anaemia. This is
best detected using the loading-pressures independent force-length relationship expressed in ESS/ESVI ratio.
Left ventricular systolic function; sickle cell anaemia; echocardiographic evaluation; adult Nigerian patients