Treadmill walking exercise modulates bone mineral status and inflammatory cytokines in obese asthmatic patients with long term intake of corticosteroids.|
El-Kader,Shehab M. Abd; Al-Jiffri,Osama H.; Ashmawy,Eman M. & Gaowgzeh,Riziq Allah M.
Background: Obesity and asthma are an important public health problem in Saudi Arabia. An increasing body of data supports
the hypothesis that obesity is a risk factor for asthma. Asthma appears to be associated with low bone mineral density (BMD)
due to long-term use of corticosteroids. Studies recently showed that weight bearing exercise training can increase mineral bone
density, reduce weight and improve metabolic control.
Objective: The present study aimed to measure the effects of treadmill walking exercises on bone mineral status and inflammatory
cytokines in obese asthmatic patients treated with long term intake of corticosteroids.
Methods: Eighty obese asthmatic patients of both sexes, their age ranged from 41 to 53 years. Subjects were divided into two
equal groups: training group (group A) received aerobic exercise training on treadmill for six months in addition to the medical
treatment where, the control group (group B) received only the medical treatment.
Results: The results of this study indicated a significant increase in BMD of the lumbar spine & the radius, serum calcium
and high density lipoprotein cholesterol (HDL-c) & significant reduction in parathyroid hormone, leptin, tumor necrosis factor–
alpha(TNF-α), interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-6 (IL-6), low density lipoprotein cholesterol (LDL-c),
triglycerides (TG) and body mass index (BMI) in group (A), while these changes were not significant in group (B).Also; there
was a significant difference between both groups at the end of the study.
Conclusion: Treadmill walking exercise training is an effective treatment policy to improve bone mineral status and modulates
inflammatory cytokines and blood lipids profile in obese asthmatic patients with long term intake of corticosteroids.
Bone mineral density; bronchial asthma; exercises; inflammatory cytokines; inhaled corticosteroids; obesity