African Health Sciences
Makerere University Medical School
Vol. 16, No. 4, 2016, pp. 1067-1077
Bioline Code: hs16138
Full paper language: English
Document type: Research Article
Document available free of charge
African Health Sciences, Vol. 16, No. 4, 2016, pp. 1067-1077
© Copyright 2016 - African Health Sciences
Opiate withdrawal syndrome in buprenorphine abusers admitted to a rehabilitation center in Tunisia.|
Derbel, Ines; Ghorbel, Asma; Akrout, Férièle Messadi & Zahaf, Abdelmajid
Background: Illicit use of high dosage buprenorphine has been well documented in several countries, including Tunisia.
Objectives: The aim of this survey is to assess the buprenorphine withdrawal syndrome time course, and how it may be affected
by the population characteristics among subjects admitted to a rehabilitation center in Tunisia.
Methods: A prospective research has permitted study of the socio-demographic characteristics and assessment of buprenorphine
withdrawal syndrome among 32 subjects admitted for buprenorphine dependence by using the clinical opiate withdrawal
scale. An ANOVA was conducted to examine the effect of different factors on the withdrawal scores.
Results: 32 subjects were included. Among them 30 were males, 27 had been injecting buprenorphine, 16 were poly-drug
abusers and 2 had a history of mental disorders. Buprenorphine withdrawal syndrome was of a mild intensity and had a delayed
onset. Withdrawal mean scores varied between 0 and 9, and maximum values were reached at day 21. These scores varied
significantly over time (p<0,001). The sex v time interaction and the mode of consumption of buprenorphine had significant
effects on the withdrawal scores (p<0,001). The poly-drug consumption and the history of mental disorders did not have any
significant effect on the withdrawal scores.
Conclusion: This study has permitted description of buprenorphine withdrawal syndrome among patients going through a
detoxification treatment at a rehabilitation center. Understanding this syndrome would help elaborate effective and suitable buprenorphine
dependence management plans.
Buprenorphine; dependence; withdrawal.