African Health Sciences
Makerere University Medical School
Vol. 16, No. 4, 2016, pp. 1143-1150
Bioline Code: hs16146
Full paper language: English
Document type: Research Article
Document available free of charge
African Health Sciences, Vol. 16, No. 4, 2016, pp. 1143-1150
© Copyright 2016 - African Health Sciences
Diagnostic accuracy of fine needle aspiration cytology in patients undergoing thyroidectomy in Uganda: tertiary hospital experience.|
Masereka, Robert; Okeny, Paul K.; Fualal, Jane O. & Wamala, Dan
Background: Thyroid disease affects about 5% of the World’s population. Fine Needle Aspiration Cytology (FNAC) helps in
planning extent of surgery. In some studies, FNAC has been found to have a low accuracy for malignancy.
Objective: To estimate the sensitivity and specificity of FNAC in detecting malignancy for thyroid disease using histopathology
as the gold standard.
Methods: Patients who underwent clinical and laboratory evaluation and thyroidectomy at Mulago National Referral hospital
and the Pathology department of Makerere University College of Health Sciences were consecutively recruited over a four
months period. Analysis using STATA version 10 focused on sensitivity, specificity and accuracy of FNAC in detecting malignancy.
Results: In total, 99 patients were recruited, the F:M ratio was 15.5:1 and median age was 42 years (IQR 34-50). The median
duration of symptoms was 364 weeks (IQR 104-986). The proportion of patients with malignancy was 13.3% with papillary
thyroid carcinoma being the most predominant type and colloid goiter was the most predominant benign thyroid disease. The
sensitivity was 61.5% and specificity 89.5% .
Conclusion: This study revealed high specificity and low sensitivity of Fine Needle Aspiration Cytology (FNAC) at detecting malignancy in thyroid nodules
Diagnostic accuracy; fine needle aspiration; cytology; thyroidectomy; tertiary hospital