African Health Sciences
Makerere University Medical School
Vol. 16, No. 4, 2016, pp. 1188-1194
Bioline Code: hs16153
Full paper language: English
Document type: Research Article
Document available free of charge
African Health Sciences, Vol. 16, No. 4, 2016, pp. 1188-1194
© Copyright 2016 - African Health Sciences
Retinal nerve fibre layer thickness values and their associations with ocular and systemic parameters in Black South Africans.|
Mashige, Khathutshelo P. & Oduntan, Olalekan A.
Purpose: To measure the retinal nerve fibre layer (RNFL) thickness values and investigate their associations with other parameters
in healthy eyes of Black South Africans.
Methods: 600 participants with healthy eyes, of whom 305 (50.83%) were males and 295 (49.17%) were females, with a mean
age of 28.15 ± 13.09 years, underwent a detailed ophthalmic examination. RNFL thickness was measured by iVue SD-OCT.
Results: The mean global RNFL thickness was 110.01 ± 7.39 μm. The RNFL was thickest inferiorly (135.06 ± 9.66 μm) and
superiorly (131.72 ± 10.46 μm), thinner nasally (87.24 ± 13.22 μm), and thinnest temporally (73.63 ± 15.66 μm). Multivariate
analysis showed that thicker mean global RNFL thickness was significantly associated with younger age, shorter axial length (AL)
and hyperopia (p < 0.001). Mean RNFL thickness decreased by approximately 0.11 μm per year of aging life, and by 1.02 μm
for each 1-mm of axial elongation. There was a 0.62 μm RNFL thickness increase for every dioptre change in spherical power
towards more hyperopia.
Conclusion: Mean RNFL thickness values and their associations established in this population may be of clinical value when
assessing factors that influence this parameter and diagnosing diseases affecting it.
Retinal nerve fibre layer; optical coherence tomography; refractive error; axial length; glaucoma