African Health Sciences
Makerere University Medical School
Vol. 17, No. 1, 2017, pp. 255-261
Bioline Code: hs17031
Full paper language: English
Document type: Research Article
Document available free of charge
African Health Sciences, Vol. 17, No. 1, 2017, pp. 255-261
© Copyright  - African Health Sciences
Hydroxyurea therapy in adult Nigerian sickle cell disease: a monocentric survey on pattern of use, clinical effects and patient’s compliance.|
Adewoyin, Ademola Samson; Oghuvwu, Omokiniovo Sunday & Awodu, Omolade Augustina
Background: The clinical prospects of hydroxyurea therapy in the management of sickle cell disease (SCD) require evaluation
in the Nigerian setting to develop indigenous guidelines. This survey examines the pattern of hydroxyurea therapy, its clinico-haematologic benefits and safety profile in Nigerian SCD subjects.
Methods: A cross sectional pilot survey was carried out among 60 adult SCD subjects over 3 months. Data on clinical phenotypes,
relevant haematological parameters and details of hydroxyurea therapy were obtained using a structured questionnaire
through an interview process and case file review.
Results: The median age was 30 years. Thirty-four (56.7%) of the subjects are aware of hydroxyurea therapy in SCD. Twenty-four (40%) SCD patients had previously used hydroxyurea. Only 4 subjects were fully compliant. Reasons for non-compliance
included poor knowledge and lack of funds. In particular, hydroxyurea reduced leucocyte count and increased mean red cell
volume (MCV) in compliant subjects.
Conclusion: Hydroxyurea use is low among Nigerian SCD subjects despite its proven efficacy/clinical prospects in the developed
nations. Large scale multicenter studies and clinical trials are needed to form a basis for developing standard local treatment
protocol for its use.
Hydroxyurea therapy; Nigerian sickle cell disease; pattern of use; clinical effects; patient’s compliance