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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 17, No. 3, 2017, pp. 923-932
Bioline Code: hs17112
Full paper language: English
Document type: Study
Document available free of charge

African Health Sciences, Vol. 17, No. 3, 2017, pp. 923-932

 en Onset and duration of cycloplegic action of 1% cyclopentolate – 1% tropicamide combination.
Kyei, Samuel; Nketsiah, Alfred Asiem; Asiedu, Kofi; Awuah, Agnes & Owusu-Ansah, Andrew


Purpose: To study the time course (onset, time and duration of maximal cycloplegia, and the full duration) of cycloplegic action of 1% Cyclopentolate – 1% Tropicamide.
Methods: Seventy-seven students, aged 15-24 years were purposively sampled from the University of Cape Coast and Cape Coast Technical Institute. Subjective near addition (ADD) determination and pupil diameter measurement before and after a drop of the test agent (1% Cyclopentolate – 1% Tropicamide combination in the right eye) and the control (1% Cyclopentolate in the left eye) were performed. Measurements of subjective near ADD and pupil diameter were made after the initial reading at 5 minutes interval for the first hour and every 30 minutes for the next 7 hours for each participant. Time of onset, time of peak cycloplegia, duration of peak cycloplegia and duration of total cycloplegic effect was indirectly determined.
Results: 1% Cyclopentolate – 1% Tropicamide combination had rapid onset of cycloplegia (5-10 minutes), shorter time of maximal cycloplegia (55 versus 90 minutes), and recovery (7 versus ≥ 8hours) in the majority (79.2%) of subjects.
Conclusion: Cyclopentolate –Tropicamide combination was comparable to Cyclopentolate in depth of cycloplegia produced, and clinically superior to 1% Cyclopentolate in rapidity of cycloplegic onset, time of maximal cycloplegia and recovery from cycloplegia.

Cycloplegia; time course; accommodation; recovery time

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