African Health Sciences
Makerere University Medical School
Vol. 18, No. 1, 2018, pp. 90-101
Bioline Code: hs18013
Full paper language: English
Document type: Study
Document available free of charge
African Health Sciences, Vol. 18, No. 1, 2018, pp. 90-101
© Copyright 2018 - African Health Sciences
Characteristics of COPD phenotypes classified according to the findings of HRCT and spirometric indices and its correlation to clinical characteristics|
Bhaskar, Ravi; Singh, Seema & Singh, Pooja
Introduction: In recent years, there has been increasing interest in diagnosing various components of chronic obstructive pulmonary
disease (COPD) using high-resolution computed tomography (HRCT). The present study was undertaken to evaluate
HRCT features in patients with COPD.
Materials and methods: Fifty patients of COPD (confirmed on Spirometry as per the GOLD guidelines 2014 guidelines)
were enrolled, out of which 35 patients got a HRCT done. The Philips computer program for lung densitometry was used with
these limits (-800/-1, 024 Hounsfield unit [HU]) to calculate densities, after validating densitometry values with phantoms. We
established the area with a free hand drawing of the region of interest, then we established limits (in HUs) and the computer
program calculated the attenuation as mean lung density (MLD) of the lower and upper lobes.
Results: There was a significant correlation between smoking index and anteroposterior tracheal diameter (P = 0.036). Tracheal
index was found to be decreasing with increasing disease severity which was statistically significant (P = 0.037). A mild linear
correlation of pre-forced expiratory volume in the first second (FEV1) was observed with lower lobe and total average MLD
while a mild linear correlation of post-FEV1 was observed with both coronal (P = 0.042) and sagittal (P = 0.001) lower lobes
MLD. In addition, there was a linear correlation between both pre (P = 0.050) and post (P = 0.024) FEV1/forced vital capacity
with sagittal lower lobe MLD.
Conclusion: HRCT may be an important additional tool in the holistic evaluation of COPD.
Chronic obstructive pulmonary disease; high resolution computed tomography; spirometry.