African Health Sciences
Makerere University Medical School
Vol. 18, No. 2, 2018, pp. 260-266
Bioline Code: hs18034
Full paper language: English
Document type: Study
Document available free of charge
African Health Sciences, Vol. 18, No. 2, 2018, pp. 260-266
© Copyright 2018 - Shen et al.
An eight cytokine signature identified from peripheral blood serves as a fingerprint for hepatocellular cancer diagnosis|
Shen, Jing; Wu, Hua; Peng, Ning & Cai, Jie
Background: Hepatocellular carcinoma is an aggressive disease in Asia and Africa with poor prognosis partially due to lack of
Objectives: The aim of this study was to assess the concentrations of different cytokines and chemokines in peripheral blood
of patients with hepatocellular carcinoma and identify the potential biomarkers that would help in clinical assessment.
Methods: Profiling of 14 cytokines, chemokines and growth factors was performed in peripheral blood of 78 patients and 78
healthy controls using Bio-Plex Human 15-plex assay kit.
Results: The results showed that patients had significantly higher levels of IL-1β (p=0.034), IL-6 (p=2.13e-06),IL-10 (p=0.013),
IL-17A (p=0.017), IL-22 (p=0.00276), IL-25 (p=0.0005), but lower levels of IL-4 (p=0.00341) and IL-33 (p=0.00982) in peripheral blood.
Conclusion: We identified a unique eight-peripheral blood cytokines signature for hepatocellular carcinoma detection. This
work will serve as the basis for further studies about the clinical value of peripheral blood cytokines in forecasting prognosis
Cytokine; peripheral blood; hepatocellular carcinoma; biomarker; diagnosis.