African Health Sciences
Makerere University Medical School
Vol. 18, No. 2, 2018, pp. 287-294
Bioline Code: hs18038
Full paper language: English
Document type: Study
Document available free of charge
African Health Sciences, Vol. 18, No. 2, 2018, pp. 287-294
© Copyright 2018 - Alkireidmi et al.
Biochemical markers as diagnostic/prognostic indicators for ischemic disease|
Alkireidmi, MA; Al-Abbasi, FA; Mehanna, MG & Moselhy, Said S
Objective: The use of a biomarker was extremely useful in clinical emergencies such as stroke to aid in triage and early management of cases. The diagnostic accuracy of laboratory biomarkers is run to approve the identification of easy, cheap and fast
tests associated with cerebral ischemia and intracranial hemorrhage. The present study was designed to screen serum enolase
activity, activities of CK-BB, LDH and lipid profile in patients with ischemic or related diseases as good diagnostic/ prognostic
indicator for ischemic diseases.
Methods: Sixty male subjects in the age range of (45 ±2years) were divided into four groups each with 15 participants: Group
(I) normal . Group (II) patients recently diagnosed as ischemic disease; Group (III) hypertensive patients and Group (IV); diabetic patients enolase activity (p<0.001) and CK-BB (p<0.01) in ischemic and hypertensive patients compared with control and
diabetic groups. LDH level was significantly elevated in ischemic, hypertensive and diabetic patients compared with controls
(p<0.001). The cut -off value for serum enolase was 62.5 nmol/l showing 90% sensitivity and 93% specificity for differentiation
of ischemic disease. Positive correlations were observed between serum enolase (r = 0.56), and CK-BB (r = 0.53).
Conclusion: Serum enolase can be considered as a more sensitive and specific marker and used as a sensitive diagnostic or
prognostic marker for ischemic related diseases.
Serum enolase; ischemia; hypertension; diagnosis; prognostic.