search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1729-0503
Vol. 18, No. 2, 2018, pp. 378-383
Bioline Code: hs18048
Full paper language: English
Document type: Study
Document available free of charge

African Health Sciences, Vol. 18, No. 2, 2018, pp. 378-383

 en Thyroid function in healthy and unhealthy preterm newborns
Korkmaz, Gökten; Özçetin, Mustafa; Çağ, Yakup; Yükselmiş, Ufuk; Öngel, Volkan & Işık, Olcay

Abstract

Background: The thyroid gland and hormonal regulation are among the most important systems to be investigated in pre-term infants. This study sought to investigate thyroid hormone levels of healthy and unhealthy pre-term infants.
Methods: The prospective study included 53 consecutive premature infants admitted to the neonatal intensive care unit within a duration of one year. Of these preterm babies, 20 were healthy, while 33 had problems such as asphyxia or RDS. Venous blood samples were collected at baseline 0-24 hours, 7 and 14 days and FT3, FT4, and TSH levels were determined. Other data recorded included demographic characteristics of the patients and clinical variables.
Results: The most frequent health problems were RDS (87.9%), sepsis (30.3%), and retinopathy of prematurity (24.2%). The mean TSH levels showed a consistent decline at three consequent measurements in both groups, which were always significantly lower in unhealthy pre-terms. In both groups, TSH levels showed significant decreases on Day 7 and Day 14 compared to the baseline levels (p<005). The levels of FT3 and FT4 consistently showed significant correlations with gestational week and birth weight at each of the three measurements.
Conclusion: Pre-term infants, especially those having problems, have significant hypothyroxinemia that may require thyroid hormone replacement therapy.

Keywords
Prematurity; hypothyroxinemia; thyroid; TSH.

 
© Copyright 2018 - Korkmaz et al.

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2019, Site last up-dated on 15-Ago-2019.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil