African Health Sciences
Makerere University Medical School
Vol. 18, No. 3, 2018, pp. 681-688
Bioline Code: hs18085
Full paper language: English
Document type: Study
Document available free of charge
African Health Sciences, Vol. 18, No. 3, 2018, pp. 681-688
© Copyright 2018 - AL-Ghamdi et al.
Serum proteins C and S levels as early biomarkers for kidney dysfunction in hemophilic patients|
AL-Ghamdi, Maryam A; Huwait, Etimad A; Kumosani, Taha A; Qari, M; Moselhy, Said S & Kumosani, Afnan T
Background: Hemophilia is an inherited genetic disease characterized by the inability to coagulate blood after injury. The rationale of the current study was to evaluate serum proteins S and C and correlate to kidney function test in hemophilic patients
for early diagnosis of abnormality in renal function.
Subjects and Methods: This study was conducted on 80 males subjects divided into four groups. Group I: Control: Healthy
subjects. Group II: Renal dysfunction (serum Creatinine >2mg/dl): Group III: Hemophilic patients. Group IV: Hemophilic
patients with renal disorder. Serum urea, creatinine, sodium, potassium, protein C and protein S level were determined.
Resuts: Protein C and S levels showed a significant decrease in hemophilic/and with renal dysfunction (P < 0.001,p<0.001).
The level of plasma protein C and S levels were positively correlated with increased urinary albumin (P < 0.01). Urinary albumin
was increased about 15 folds in hemophilic patients with renal dysfunction and nephrotic patients as compared with the control
group. The cut-off value in 90% patients at the hemophilic patients with renal dysfunction 70%. Positive correlations were
observed between urinary albumin (r=0.66), and creatinine (r=0.73).
Conclusion: These biomarkers showed good predictive values with regard to ROC-AUC (0.41 and 0.75 for Proteins C and S,
Hemophilia; renal dysfunction; protein C; protein S.