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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 18, No. 4, 2018, pp. 865-872
Bioline Code: hs18106
Full paper language: English
Document type: Study
Document available free of charge

African Health Sciences, Vol. 18, No. 4, 2018, pp. 865-872

 en HMGA1 variant IVS5-13insC is associated with insulin resistance and type 2 diabetes: an updated meta-analysis
Liu, Yancheng; Zheng, Liting; Kong, Hao; Wang, Qinglu & Tian, Xuewen


Background: High-mobility group A1 (HMGA1) polymorphism has been suspected as a gene variant associated with type 2 diabetes (T2D). However, conflicting outcomes have been reported.
Objective: This meta-analysis aimed to predict the association between the HMGA1 variant IVS5-13insC and T2D.
Methods: Statistical analyses were performed using Stata/SE 12.0 software.
Results: A total of 11 case-control studies in 6 articles were included. Results suggested that the HMGA1 variant IVS5-13insC was associated with an increased risk of insulin resistance (OR = 0.61, 95% CI 0.56 to 0.66, P < 0.0001), T2D (OR = 0.67, 95% CI 0.61 to 0.73, P < 0.0001), particularly for Caucasians with increased risks of T2D (OR = 0.56, 95% CI 0.49 to 0.65, P < 0.0001) compared with wild-type subjects.
Conclusion: This meta-analysis indicated that the HMGA1 variant IVS5-13insC can be a risk factor of T2D development, particularly among Caucasians. Significant risks were also found (Asian: OR = 0.74, 95% CI: 0.63 to 0.86, P < 0.0001, Hispanic-American: OR = 0.81, 95% CI: 0.65 to 1.01, P < 0.0001) in non-Caucasian population. However, ethnical studies should be conducted to reveal whether the HMGA1 variant IVS5-13insC is associated with an increased risk of T2D.

HMGA1; type 2 diabetes; insulin resistance; variant; meta-analysis.

© Copyright 2018 - Liu et al.

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