Association of FokI, TaqI, BsmI and ApaI polymorphisms with diabetic retinopathy: a pooled analysis of case-control studies|
Jiao, JingHua; Li, Yan; Xu, Shuang; Wu, Jingyang; Yue, Song & Liu, Lei
Background: To assess synthetically the association between polymorphisms in the vitamin D receptor (VDR) gene (FokI,
BsmI, ApaI, and TaqI) and diabetic retinopathy (DR).
Methods: Pubmed, Embase, ISI Web of Science, Google-scholar and CBMDisc, CNKI and Chongqing VIP databases were
searched. A meta-analysis was performed.
Results: Six studies with 636 cases and 1,035 controls were included in this meta-analysis. The outcomes showed that the FokI
polymorphism (F allele) of VDR gene had no statistical protective relationship with DR in overall studies. Interestingly, stratification analysis showed that the FokI polymorphism (Fallele) was significantly associated with decreased DR risk in the Chinese
population, among included studies without publication bias, during a comparison analysis between normal subjects and DR
patients, and among articles published after 2010. However, the TaqI, BsmI and ApaI polymorphisms of VDR gene had no
significant association with the risk of DR.
Conclusion: This meta-analysis of case-control studies revealed that the VDR-FokI polymorphism (F allele) decreased the risk
of DR in Chinese people, among included studies without publication bias, during a comparison analysis between normal subjects and DR patients, and among articles published after 2010. Further rigorous and prospective studies with large sample size
are needed to confirm our findings.
Diabetic retinopathy; polymorphism; Vitamin D receptor.