African Health Sciences
Makerere University Medical School
Vol. 18, No. 4, 2018, pp. 909-916
Bioline Code: hs18111
Full paper language: English
Document type: Study
Document available free of charge
African Health Sciences, Vol. 18, No. 4, 2018, pp. 909-916
© Copyright 2018 - Businge et al.
Diagnostic performance of several biomarkers for identification of cases of non-communicable diseases among Central Africans|
Businge, Charles Bitamazire; Longo-Mbenza, Benjamin; Adeniyi, Oladele Vincent; Muaka, Moise Mvitu; Lelo, Georges Mvumbi; Nkanga, Mireille Solange Nganga; Kavembe, Jean-Marie; Buassa-bu-Tsumbu, Baudoin; Kabangu, Jean-Rene’ M’buyamba & Ter Goon, Daniel
Background: This study determined the diagnostic performance of new biomarkers for a composite diagnosis of non-communicable diseases (NCDs) among Central Africans.
Methods: This case-control study was conducted at LOMO Medical Centre, Kinshasa, DR Congo (DRC) between January
– December, 2008. The cases comprised 226 participants with concurrent presence of at least 2 or more of NCDs. Anthropometric parameters and blood pressure were measured while blood samples were assayed for biomarkers. The receiver operating
characteristics curve and the logistic regression model were applied.
Results: Serum selenium (Se) had specificity and sensitivity of 72.4% and 91.1%, respectively with an area under the curve
(AUC) of 0.802; Nitric oxide (NO) (specificity: 72.4%; sensitivity: 93.0%) (AUC = 0.800); Thyroid stimulating hormone (TSH)
levels > 6 Mu/L (specificity: 75%; sensitivity: 65%) (AUC = 0.0.727); serum calcium levels of ≥ 110g/L (specificity: 76%; sensitivity: 75%) (AUC = 0.822); and daily salt intake of ≥10 g/day (specificity: 75%; sensitivity: 67%) (AUC = 0.653) in the diagnosis
of all NCDs, which were all highly significant (<0.0001).
Conclusion: Serum Se, NO, calcium, TSH and daily salt intake had high diagnostic performance as biomarkers for identification
of patients with concurrent NCDs in the study population.
Non-communicable diseases; diet; new biomarkers; Central Africa.